PROJECT REVIEW “Endogenous Testosterone, Testosterone Precursors And Metabolites; 19-Nor-Steroids and Establishment of Normal Urinary Levels Of These And Related Compounds”

Recently, a sizeable number of urine samples analysed by official laboratories tested positive (>2ngIml) for the nandrolone metabolites 1 9nortestosterone (19-NT), 1 9-norandrosterone (19-NA) and 19noretiocholanolone (19-NE) (1-6). The large number of positive tests in such a short period of time, combined with the fact that some sports involved had not previously been associated with the abuse of anabolic-androgenic steroids (e.g. judo, handball, football and figure skating) have triggered investigations into the possible endogenous production of these metabolites in the adult male (1,3). The JOC and other bodies have concluded that more studies are necessary to fully elucidate the metabolic fate of anabolicandrogenic steroids (AAS) for the parent hormone, its precursors and metabolites.